Anabolic-androgenic steroids are man-made substances related to male sex hormones. “Anabolic” refers to muscle-building, and “androgenic” refers to increased masculine characteristics. “Steroids” refers to the class of drugs. These drugs are available legally only by prescription, to treat conditions that occur when the body produces abnormally low amounts of testosterone, such as delayed puberty and some types of impotence. They are also prescribed to treat body wasting in patients with AIDS and other diseases that result in loss of lean muscle mass. Abuse of anabolic steroids, however, can lead to serious health problems, some irreversible.

Today, athletes and others abuse anabolic steroids to enhance performance and also to improve physical appearance. Anabolic steroids are taken orally or injected, typically in cycles of weeks or months (referred to as “cycling”), rather than continuously. Cycling involves taking multiple doses of steroids over a specific period of time, stopping for a period, and starting again. In addition, users often combine several different types of steroids to maximize their effectiveness while minimizing negative effects (referred to as “stacking”).

Health Hazards

• For men — shrinking of the testicles, reduced sperm count, infertility, baldness, development of breasts, increased risk for prostate cancer.
  
• For women — growth of facial hair, male-pattern baldness, changes in or cessation of the menstrual cycle, enlargement of the clitoris, deepened voice.
  
• For adolescents — growth halted prematurely through premature skeletal maturation and accelerated puberty changes. This means that adolescents risk remaining short for the remainder of their lives if they take anabolic steroids before the typical adolescent growth spurt.

In addition, people who inject anabolic steroids run the added risk of contracting or transmitting HIV/AIDS or hepatitis, which causes serious damage to the liver.

Scientific research also shows that aggression and other psychiatric side effects may result from abuse of anabolic steroids. Many users report feeling good about themselves while on anabolic steroids, but researchers report that extreme mood swings also can occur, including manic-like symptoms leading to violence. Depression often is seen when the drugs are stopped and may contribute to dependence on anabolic steroids. Researchers report also that users may suffer from paranoid jealousy, extreme irritability, delusions, and impaired judgment stemming from feelings of invincibility. 1

Research also indicates that some users might turn to other drugs to alleviate some of the negative effects of anabolic steroids. For example, a study of 227 men admitted in 1999 to a private treatment center for dependence on heroin or other opioids found that 9.3 percent had abused anabolic steroids before trying any other illicit drug. Of these 9.3 percent, 86 percent first used opioids to counteract insomnia and irritability resulting from the anabolic steroids.

1. Inhibition of Natural Hormones

The inhibition of natural hormones is probably the most common and probable side effect experienced from the use of anabolic steroids. In almost all cases, adding a hormone into your body will send a message to your endocrine system to stop producing it. This is because your body wants to remain in a very balanced state -- called "homeostasis," To maintain homeostasis, the body wants to avoid having too much of any particular hormone. To achieve this, the body sends a message to the testicles to slow down, or even stop producing testosterone when there is too much circulating. Unfortunately, this happens when any kind of hormone is added into the body, so even if an athlete is not using testosterone, but is using other anabolic steroids, the body will still send this signal 99% of the time. Of course different steroids cause varying degrees of inhibition ranging from total shut down of endogenous (natural) testosterone production, to very mild inhibition, where some natural hormones are still being produced and circulating. In almost all cases, this inhibition is over once the steroids aren´t active in the body anymore. In the following charts, we can see a mirror image of the level of steroid in the body (Nandrolone), compared with the level of natural testosterone being produced.

2. Steroid Effects and Liver Damage

Liver damage is probably the most sensationalized of all side effects possible from steroid use. The media often focuses on this particular problem as if it occurs with every steroid, and in every person who takes them. Nothing could be further than the truth. Most anabolic steroids which are ingested orally pass through the liver, which functions as the body´s filtration system. When something goes through the liver, it is broken down by various enzymes, and passed along into the bloodstream. Most research on orally administered anabolic steroids focus on the fact that liver enzymes are elevated following ingestion.

3. Steroid Effects on Cholesterol (Blood Lipid Profile)

Steroids can, in fact lower HDL cholesterol and raise LDL cholesterol. HDL (high density lipoprotein, commonly referred to as "good cholesterol") helps to protect the arteries by bringing unused cholesterol to the liver where it is broken down. LDL on the other hand has the opposite effect. Some steroids can therefore cause high cholesterol levels with low HDL and high LDL. Some steroids are, of course, very mild on blood lipids, while others are notably harsh.

4. Gynocomastia (Development of breast tissue in males)

The development of gynecomastia or feminization of the breast tissue in males is possible with anabolic steroids. This is due to an excess of estrogen being present in the body, through a process known as "aromatization" whereby androgens like testosterone are converted to estrogen. This excess estrogen then finds its way to the receptors in breast tissue and binds to them. This results in the possibility of female-like breast tissue, which must sometimes be removed by surgery. Most athletes experience itchiness of the nipples, followed by pain. Since this develops over several days, usually, the athlete usually has more than enough time to discontinue the use of the compounds he´s taking, or to attempt to counteract the breast tissue development while remaining on the cycle. The two most common ways this is achieved by steroid users is either to use an anti-estrogen like Nolvadex or Arimidex in their cycle or to take Letrozole (*a very strong Aromatase Inhibitor and antiestrogenic compound) afterwards, to destroy the tissue that has developed.

Male breast development occurs in basically the same way as female breast development, and the use of anabolic steroids can result in this happening at a later stage in life for males. At puberty a surplus of hormones all combine to stimulate the growth and development of breast tissue.

5. Acne and Anabolic Steroids

Anabolic steroids can cause the Development of acne and the extent to which it is experienced can be due to a number of varying factors, with the particular steroids and exact dosages used being the two primary factors. The skin´s sebaceous glands have a particularly high affinity to Dihydrotestosterone, which is an androgen the body naturally produces from testosterone via the enzyme 5-alpha Reductase. Increased sebaceous gland activity can oily skin which can combine with bacteria and dead skin caused by normal wear and tear, eventually causing pores to become clogged more quickly than the body can remove them. This of course, is preventable by using only particular steroids, cleansing the skin regularly, and perhaps using a topical anti-androgen.

6. Roid Rage

Increased aggressiveness is often claimed to occur with anabolic steroid use. Although it´s highly rare (less than 5%), significant psychiatric symptoms have been found in some steroid users, including aggression and increased violence, mania, and even psychosis. However, it must be noted that in the studies done without a control group, it can safely be assumed that naturally aggressive people simply just be more inclined to use steroids (type-A personalities, if you will). This would probably have an effect on possibly skewing the results. Certainly, if someone takes the risk to use steroids to improve their performance in a sport or their physique, they have certain aggressive traits. Can steroids enhance them? Possibly. Can steroids be to blame for anti-social, psychotic, "roid-rage" type behavior? Probably not. The evidence just isn´t there to support that.

7. Virilization (Development of male characteristics in women)

This term refers masculinization, or development of male sexual characteristics that females could potentially suffer from steroid use. This side effect on women is often reversible after the cycle has ended. Some typical signs of virilization are the development of a deeper voice, hirsuitism (growth of excess body hair), enlargement of external genitalia (clitoral enlargement), and possible male pattern baldness, or acne on the face or body. This is all dependent, of course, on the compounds used as well as the dosages employed. Personally, I have witnessed the most permanent of these effects to be the deepening of the voice due to the hypertrophy (growth) of the vocal chords. This is typically the most unwelcome side effect, as it makes it very obvious when a woman is using steroids. Of course, if this begins, the best course of action is to cease taking all steroids immediately. There are several ways to reverse this effect, the most common being to undergo a medical procedure known as vocal chord scraping. And yes, it´s exactly what it sounds like.

8. Stunted Growth (height)

The use of some steroids can possibly stunt the growth potential of people who have not finished growing. This is only possible with certain steroids, and not with others. In fact, certain steroids have been used in clinical settings to improve growth rates in children. It is probable that the premature closure of the epiphysial cartilage, which is most likely caused by aromatizable steroids, will lead to a possible growth inhibiting effect, and could ultimately result in a shorter adult height. This most likely an irreversible side effect, as the growth plates would have sealed and can not "re-open". Anavar (Oxandrolone) has been used to improve the height of growth stunted children, and it is probable that most DHT-derived steroids could also be used for this purpose as could certain anti-estrogens.

9. High Blood Pressure

This problem is possibly the most easily remedied of all steroid side effects. It' s very common for steroid using athletes attempting to gain maximum bulk to abstain from all aerobic activity. This causes the body to work much harder to circulate blood. Also, the typical water and sodium retention induced by certain steroids can contribute to this. If blood pressure is measured regularly to ensure that the value is not higher than 140/90, there should be no problems.

Anabolic Steroid Side Effects are a very real and possible concern for those who decide to use them.

Source: http://www.drugabuse.gov, http://www.steroid.com